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Introduction Ovarian cancer (OC) remains the most lethal gynecological cancer, largely due to its late diagnosis, frequent recurrence, and resistance to chemotherapy ( Beyond the M1/M2 paradigm: macrophage diversity in ovarian cancer Emerging evidence indicates that the macrophage landscape in ovarian cancer is highly heterogeneous, both across different patients (intertumoral heterogeneity) and within individual tumors (intratumoral heterogeneity)