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however, their expression is also modulated by the microbiota and other metabolites ( Lactobacillus spp., not only maintains an acidic environment but also diminishes MMP activity by inhibiting the production of pro-inflammatory factors ( 5.3.2 Influence on metabolism and signalling in fetal membrane cells Vaginal microbiota and their metabolites can regulate the function and structure of fetal membranes by influencing the metabolism and signaling of fetal membrane cells ( Lactobacillus , including lactic acid and hydrogen peroxide, are essential for preserving the balance of fetal membrane cells and for inhibiting harmful bacteria