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Fuggle N, Laslop A, Rizzoli R, Al-Daghri N, Alokail M, Balkowiec-Iskra E et al

The two most traditional approaches are dynamical downscaling and statistical downscaling (Hewitson and Crane, 1996

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There is no clear simple relationship between maternal folate status and these fetal abnormalities, although overall the lower the maternal folate, the greater the risk to the fetus