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Numerous studies have shown that lactoferrin (Lf) receptors (LfRs), expressed on the capillary endothelial cells of the brain, transport Lf across the BBB through transcytosis [23, 24]

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Beyond drug sensitization, palmitoylation also intersects with the DDR, where loss of ZDHHC8 impairs G2/M checkpoint activation, inducing CIN and enhancing radiosensitivity [177]