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Advances in spatial multiomics and single-cell transcriptomic techniques, along with insights into aberrant signaling via myokines, cytokines, hormones, the gut microbiota, and exosomes, have revealed the molecular heterogeneity and dynamic inter-organ crosstalk underlying diabetes

While certain preconditioning methods can enhance EVs targeting and regenerative capacity, they may also trigger non-specific immune responses or accelerate systemic clearance, thereby affecting both therapeutic outcomes and safety profiles [197]

D-3-Phosphoglycerate Dehydrogenase

Therefore, interventions targeting the gut microbiota may increase the levels of BH4 in the body, which can be beneficial for human health, especially for patients with congenital biopterin deficiency

This advanced probiotic technology helps maintain a balanced intestinal flora, promoting better digestion and a stronger immune system