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The Nrf2/HO-1 signaling cascade emerges as a crucial therapeutic target in H/R-induced OS management

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The main DAMPs include ATP, calreticulin (CRT), high mobility group box protein B1 (HMGB1), heat shock protein (HSP), type I interferon (IFN I) and Annexin 1 (ANXA1), which then activate and recruit APCs such as macrophages and DCs to activate T cells reactive to tumor antigens