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1 Introduction Demyelinating diseases are mainly characterized by damage to the myelin sheath wrapping the central nervous system (CNS) axons or to oligodendrocytes themselves ( The main representative group of these primary demyelinating spectrum disorders are multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), acute disseminated encephalomyelitis (ADEM) and myelin oligodendrocyte glycoprotein associated diseases (MOGAD)

doi: 10.3389/fmed.2025.1643415 Received 08 June 2025 Accepted 25 September 2025 Published 14 October 2025 Volume 12 - 2025 Edited by Xin Hu, National Center for Child Health and Development (NCCHD), Japan Reviewed by Hua Miao, Northwest University, China Allan Kardec Barros, Universidade Federal do Maranho, Brazil ChandraShekar Annamalai, MVM College of Allied Health Sciences, India Updates Copyright 2025 Wang, Yuan, Wu and Ou

Suitable Age: 7 years and older Main Ingredients and Content per 6 Tablets (Adult Daily Dose): Ascorbic Acid (Vitamin C) 2000mg L-Cysteine 240mg Succinic Acid d--Tocopheryl (Natural Vitamin E) 50mg Riboflavin (Vitamin B2) 6mg Pyridoxine Hydrochloride (Vitamin B6) 12mg Niacinamide (Vitamin B3) 60mg Calcium Pantothenate 24mg Official Price: 180 tablets / 7,260 JPY DOKODEMO Special Price: 180 tablets / 3,200 JPY \Check the Current Lowest Price/ All Transino Products Features: Vitamin C as the main agent, L-Cysteine to alleviate pigmentation, also contains Calcium Pantothenate, Vitamin B6, and Biotin to support normal skin metabolism

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Growth retardation was observed in rats after two generations of selenium deficiency 62