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During states of chronic illness, intense physical stress, or prolonged viral infection, the body's demand for carnitine can rapidly outpace its ability to synthesize or absorb it

For instance, investigations into defective immunometabolism in CF macrophages have utilized the Seahorse Extracellular Flux analyzer, revealing impaired oxygen consumption, both at baseline and following infection with challenging pathogens like Burkholderia cenocepacia (Hamilton et al., 2021)

M1 macrophages also interact with alveolar epithelial cells, potentially inducing epithelial cell death and contributing to fibrosis through mechanisms that involve oxidative stress and cytokine-mediated damage (267)

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Interaction result: Increased risk of serotonin syndrome