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With these pharmacological doses or macrodoses, the resulting excess is excreted in the urine, as it has been unable to bind to the intrinsic factor or fully bind to transcobalamin because it has exceeded the binding capacity of the transport protein due to being present in very high doses (doses that will have been necessary, however, to ensure a specific absorption according to the objective and purpose)

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For example, with Nigerian dwarf goats its not unusual for a doe to have 3 to 5 kids at one time