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Thus, most patients are seen initially for symptoms of the associated GERD such as heartburn, regurgitation, and dysphagia

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Because your intestines can only absorb so much at once, and your kidneys continuously waste it, a single large daily dose would simply be excreted, leaving your heart and muscles unprotected for the rest of the day [11] [7]

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Oxygen sensing and the molecular stratagems underlying the process have been the focus of an endless number of investigations trying to find an answer to the question: "What is the identity of the oxygen sensor?" Dynamic changes in p O 2 constitute a potential signaling mechanism for the regulation of the expression and activation of reduction-oxidation (redox)-sensitive and oxygen-responsive transcription factors, apoptosis-signaling molecules and inflammatory cytokines