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In sepsis, a disease fundamentally characterized by immune-metabolic dysregulation, this metabolic correction capability of alkaloids targets the energetic foundation of inflammation

Sports Med 49 (Suppl 2), 169184 (2019)

These results indicate that organic oxidants induce cardiomyocyte ferroptosis through GSH depletion and GPX4 downregulation

PROTACs, heterobifunctional molecules comprised of functional ligands for POI and E3 ligases that are bridged by a linker, offer robust protein degradation/inhibition efficacy surpassing small-molecule inhibitors 35 , primarily owing to their catalytic nature 36

Priority was given to studies that included quantitative antimicrobial endpoints (e.g., MICs, biofilm assays), mechanistic validation (e.g., thiol modification, redox perturbation, signaling pathway engagement), in vivo infection or inflammation models, or human PK/PD or biomarker data