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In histamine intolerance, the body cannot break down histamine efficiently, often due to low levels of diamine oxidase (DAO) enzyme or impaired methylation pathways

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Fluorescence detection in transfected HEK293 cells demonstrated that this combination yielded 1.3 times more GFP-positive cells than alone and 300 times more than unmodified mRNA [251]

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Transiently, ECF osmolarity is higher than ICF osmolarity, which causes water to shift from ICF to ECF, decreasing ICF volume and increasing ECF volume