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Injury 49 , 14581460 (2018)

doi: 10.1016/0030-4220(87)90254-4 75 HashemA

91 Although autophagosomes are often increased in MASLD, reductions in BECN1 and accumulation of p62/SQSTM1 indicate defective lysosomal degradation and impaired autophagic flux.1, 92 This dysfunction affects lipophagy, insulin signaling, inflammatory responses, and cellular stress pathways