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M.FlurkeyK.et al (2009)

A plasma sample will have a low drug concentration in proportion to the original dose and therefore will have a high numerical value for Vd c

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More importantly, with the combination of adding L-lysine with glucoseglycerol co-fermentation, the production of -PL could be further increased to 37.6 g/L under optimal conditions, suggesting that the bottleneck of -PL synthesis is the availability of L-lysine [99]