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Histologically, IPF is defined by the usual interstitial pneumonia (UIP) pattern, characterized by patchy fibrosis, fibroblastic foci, and honeycombing ( 1.3 Ferroptosis and IPF Ferroptosis, a unique form of cell death derived by iron overload and lipid peroxidation, has emerged as a critical contributor to oxidative stress and chronic inflammation in IPF

GGT activity was calculated by obtaining the slope of the linear range of each sample (Abs per min) and dividing by the slope of a 4-nitroaniline standard curve (Abs per nmoles pNA) and by the protein mass (mg) to determine the reaction rate of the sample (nmoles pNA min 1 mg 1 )

Probiotics Probiotics are live microorganisms that can enhance gut health and reduce inflammation [81]

doi: 10.3322/caac.21834 2

Lifestyle choices: Consuming alcohol or smoking cigarettes significantly depletes cellular glutathione