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Moreover, clinical studies suggested that estradiol treatment was able to revert endothelial dysfunction in post-menopausal women with atherosclerotic, non-stenotic arteries by preventing acetylcholine-induced coronary vasospasm (114)

Metabolic and Endocrine Effects: Investigations have explored its potential impact on metabolic regulation and tissue homeostasis, though these findings remain preliminary and require further validation

However, through studies on soluble ICs and their effects, it was observed that the fate of ICs in blood circulation is either to initiate immunopathological outcomes, or to react with receptors on immune cells initiating immunological regulations

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