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This review provides evidence to support the hypothesis that the prevention of vaccine serotype pneumococcal OM in early life leads to a reduction of subsequent and more-complex disease caused by non-vaccine serotypes and non-typeable

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Wang C, Chen S, Guo H, Jiang H, Liu H, Fu H, et al

This leads to accumulation of drugs in the body which are metabolized in liver, and eventually causes an increase in the effect and adverse effects as well