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The peptide should be administered at least 30 minutes before food intake, with hydration maintained throughout the absorption window to support subcutaneous diffusion and lymphatic clearance

Claude Cohen Trends in Medicinal Chemistry Elsevier Science Publisher 1989 Analysis of the Predicted Bioactive Conformation articles Structure-based drug design and the discovery of aliskiren (Tekturna): perseverance and creativity to overcome a R and D pipeline challenge Nissim Claude Cohen Chem Biol Drug Des 70(6) 2007 10.1111/j.1747-0285.2007.00599.x Design and Syntheses of Novel 2,7-Dialkyl substituted5(S)-Amino-4(S)-Hydroxy-8-Phenyl-Octanecarboxamides as in vitro Potent Peptidomimetic Inhibitors of Humain Renin Goeschke R, Cohen NC, Wood JM and Maibaum J Bioorg

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