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Their analysis also emphasized that some medications administered in ICU care may distort systemic metabolites or cerebral uptake and that these effects should be considered in the interpretation of clinical data [50]

The superfamily of human soluble GSTs is further divided into eight separate classes: Alpha (A1A4), Kappa (K1), Mu (M1M5), Pi (P1), Sigma (S1), Theta (T1T2), Zeta (Z1) and Omega (O1O2) (Hayes et al., 2005)

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Mechanistically, ALM activates retinoid X receptor- (RXR) through stable hydrogen bond formation, thereby upregulating caudal-type homeobox transcription factor 2 (CDX2) and cystic fibrosis transmembrane conductance regulator (CFTR), while concurrently suppressing -catenin/Snail-mediated epithelial-mesenchymal transition (EMT)