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Abrine, an IDO1 inhibitor, suppresses the immune escape and enhances the immunotherapy of anti-PD-1 antibody in hepatocellular carcinoma

Currently developed DPP1 inhibitors are all oral formulations, while many NSP inhibitors require inhalation administration ( However, DPP1 inhibition also has some potential disadvantages, including slower onset (approximately 20 days to achieve maximum effects) and possible systemic side effects such as hyperkeratosis and periodontitis

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Research is ongoing to better understand how oral delivery compares to other forms