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The concentrations were measured using Tunable Resistive Pulse Sensing (TRPS) from Izon Sciences

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Opiates bind primarily to mu-opioid receptors located throughout the central nervous system, particularly in areas responsible for pain modulation, reward, motivation, and emotional regulation

Notably, the versatility of the key regulators of mitochondrial biogenesis (PGC1, NRF2) and mitophagy (Parkin) may further underline that these two processes are balanced and constrained with each other in order to control mitochondrial function under multiple physiological conditions