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The initial influx of eosinophils peaked at day 25 to 30 p.i., when around 70% of all viable cells were eosinophils, and was followed by a rapid decline thereafter, whereas the size of the skin lesions continuously increased during the observation period ( Figure 1A , right)

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2-cyano-3,12 dioxooleana-1,9 diene-28-imidazolide (CDDO-Im) and 2-cyano-3,12 dioxooleana-1,9, diene-28-methyl ester (CDDO-Me) induce caspase-independent cell death in pancreatic cancer in vitro and prevent the growth of pancreatic cancer xenografts in vivo