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The following screen shots are of NICE Guidelines Do not do recommendations for CFS/ME It is a really tricky page to find (and has a habit of hiding) so here is the link

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Okuno K, Sugiura F, Inoue K, Sukegawa Y

PPARgamma coactivator-1alpha (PGC-1alpha) protects neuroblastoma cells against amyloid-beta (Abeta) induced cell death and neuroinflammation via NF-kappaB pathway

Requirements of vitamin B 12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with intranasal or oral supplementation