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The reasons: Receptor sensitivity: While GHK-Cu doesn't appear to cause receptor downregulation the way some peptides do, cycling is a general precaution to maintain responsiveness and avoid adaptations that might blunt benefits

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10.1111/bdi.12682 355 PalaciosN.HannounA.FlahiveJ.WardD.GoostreyK.DebA.et al

For example, normalization of ALT and AST levels can alleviate symptoms of liver dysfunction such as fatigue, abdominal discomfort, and jaundice, thereby improving patients quality of life and daily activity ability