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These transitions are context-dependent and potentially reversible, representing how astrocytes shift between distinct molecular and functional profiles in response to physiological or pathological stimuli

This is because PCA can increase glutamate levels in the brain, which can cause overstimulation and lead to headaches

There has been some commentary on a 'reverse reaction' in which tetrahydrobiopterin (BH4) is produced when 5-methyltetrahydrofolate is converted back into methylenetetrahydrofolate

Supplementary material The Supplementary Material for this article can be found online at: References 1 AssimonM

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