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For decades, the standard response to joint, tendon, or muscle pain was a combination of rest, ice, and non-steroidal anti-inflammatory drugs (NSAIDs)

For instance, NKCC2 has been found in insulin-secreting -cells (Zhu et al., 2011) or neurons of the hypothalamus (Konopacka et al., 2015), whereas NCC was detected in endothelial and smooth muscle cells, heart, lung and liver (Wang et al., 2015), adipocytes (Zhang et al., 2022a), and -cells as well (Zhang et al., 2022b)

I am a trite over nervous to say the least and a dab hand at conjuring up worst case scenarios

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This is not a universal rule