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(3) Availability of pre-Everolimus treatment FFPE tumor specimens (obtained from prior nephrectomy)

6 NLRP3 inflammasome 6.1 Dual-signal activation and pyroptosis The NLRP3 inflammasome, composed of NLRP3, apoptosis-associated speck-like protein containing a CARD (ASC), and pro-caspase-1, serves as a critical innate immune sensor that mediates pro-inflammatory cytokine release in response to various PAMPs and damage-associated molecular patterns (Li et al., 2019