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This significantly enhanced the accumulation of cisplatin in tumor cells, increasing efficacy in cisplatin resistant cells and decreased tossicity 95

Efruxifermin (formerly AKR-001, AMG 876), the only other FGF21 analog studied in a clinical trial of biopsy-confirmed NASH patients, is a 92 kDa Fc-FGF21fusion protein with a 33.5 day half-life (based on intact C-terminal domain of the FGF21 moiety), which is substantially extended relative to the FGF21 analogs described above

75 In summary, we conclude that NBDHEX and its analogs may serve as potential treatment strategies in the management of patients with melanoma

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Ahmad, S