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A recent study demonstrated that disrupted GH signaling is associated with elevated p53 in colon tissue in humans and mice and that GH may act as a tumor promoter by suppressing p53, PTEN, and APC levels

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5.3.6 Dopamine Recent studies have demonstrated that certain gut microbes can synthesize dopamine or its precursors through specific metabolic pathways, thereby indirectly regulating host physiological functions, and dopamine can stabilize GPX4 and mitigate ferroptosis-related oxidative stress (171)

Excess alcohol consumption has a directly toxic effect on the gut epithelium, leading to loss of mucosal integrity and leakage of microbial products into the circulation