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Weeks 4-8: Continued healing, tissue remodeling, and functional improvement

NAD + is required for maintaining the activity of the sirtuin class of HDACs, which NAM inhibits (90)

164 In the second study, patients were randomly allocated to receive either 10 mL lidocaine solution (10 mL2% lidocaine, 3 mL 8.4% sodium bicarbonate, 2 mL pH 7.2 sterile water) or 15 mL heparin-lidocaine combined (50,000 units heparin, 200 mg lidocaine hydrochloride) and followed for 24 hours