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Although less common in this form than cyanocobalamine and methylcobalamine, hydroxocobalamine is also available as pills for oral or sublingual administration

Moreover, BNIP3L/NIX functions as a selective receptor for autophagy that is highly expressed in tumor cells, which is crucial to promote mitophagy under hypoxic TME through NFE2L2/NRF2 transactivation

Blood Cancer J 11:24 Moreau P, Parmar G, Prince M, Ocio E, Karanes C, Madan S et al 2021 A multi-center, Phase 1b study to assess the safety, pharmacokinetics and efficacy of subcutaneous isatuximab plus pomalidomide and dexamethasone, in patients with relapsed/refractory multiple myeloma