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Robert Naviaux, published in PNAS, demonstrated that ME/CFS represents a concerted "hypometabolic" state, similar to a survival hibernation mode found in some organisms facing harsh environmental stress

However, some individuals may experience mild side effects like stomach upset, bloating, or allergic reactions

The fluorescent signals peaked 8 h after administration and persisted for up to 48 h, indicating superior brain targeting and prolonged brain residence

Given the similarities between Mn and iron (Fe), homeostasis of both metals is interdependent, thus the Fe status also influences Mn accumulation