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Wernerman J Journal article: CLINICAL NUTRITION ESPEN

Conditions such as renal impairment (creatinine clearance under 60 mL per minute or clinically significant elevated serum creatinine), anemia, diabetes mellitus, electrolyte imbalance, vitamin B deficiency, and debilitating disease may enhance the occurrence of peripheral neuropathy

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Failure of these systems results in the accumulation of misfolded or aggregated proteins, organelle dysfunction, cellular injury, and disease progression across a wide spectrum of conditions, including neurodegeneration, cancer, cardiovascular and metabolic diseases