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They concluded that while GHK-Cu does demonstrate anti-wrinkle effects in cellular studies, "there is a surprising absence of clinical studies using them." The review identified skin permeation as the central challenge: GHK's high aqueous solubility and low partition coefficient work against transdermal absorption

The awareness around injecting yourself with something [like NAD, vitamins or peptides] has drastically changed over the past year, Remedy Place founder Jonathan Leary, D.C., told Glossy

High-purity GHK-Cu refers to peptide material that has undergone rigorous purification processes to support reproducibility and reliability in biochemical research studies

However, there is little to no evidence to support these claims