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Lactis HN019 and Lacticaseibacillus casei 01 reduced alveolar bone destruction and intestinal permeability while increasing estradiol levels in OVX rats (265)

Cell 182, 14191440.e23

10.1001/jama.2013.280319 78 OstromQ

Therapeutic strategies targeting this metabolic vulnerability, ranging from direct enzyme inhibition to modulation of upstream signals, have demonstrated compelling efficacy in preclinical models

Moreover, detecting abnormalities in these signaling pathways can aid in identifying the DNA, mRNA and protein mutations present in cancer cells, and may play a significant role in determining the efficacy of specific targeted therapies (Waarts et al., 2022