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Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses

10.1126/science.1164382 211 PasiniB.StratakisC

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In PD models, the use of dependent sodium channel blockers reduces glutamatergic hyperactivity and inhibits abnormal glutamate release, suggesting that amino acid metabolism disturbances may contribute to neurotoxicity and oxidative toxicity, ultimately resulting in dopaminergic neuron death [85]