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Patients who had been receiving the peptide from compounding sources lost access

Swelling, inflammation and soreness at the injection site mostly occurs within days to weeks of vaccination, and is usually self-limiting or responds well to topical symptomatic treatment

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After starting and after each dose increase, tirzepatide can cut the peak absorption of an oral contraceptive by more than half, so the label guidance is a non-oral method or added barrier protection for four weeks after starting and four weeks after each increase. It is a first-dose-and-escalation effect, not a permanent block on all oral drugs