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Although the matched estimates remained directionally consistent with the regression findings, the loss of statistical significance after balancing observed confounders suggests that unmeasured confounding particularly by body mass index and health motivation likely explains a substantial share of the associations detected in conventionally adjusted models

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We extracted 51 observations from 11 prospective cohort studies and 4 casecontrol studies across 36 locations (Supplementary Table 3) 6,8,9,10,78,108,109,110,111,112,113,114,115,116

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