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It was reported that intraperitoneal injection of deferoxamine (DFO) induced focal cerebral ischemic tolerance, reduced the size of cerebral infarction, improved neurological function, and protected cultured cortical neurons from oxygen-glucose deprivation (OGD) ( Iron Metabolism-Related Proteins and Stroke Iron metabolism iron metabolism mainly involves iron influx and iron outflow, and these two processes largely depend on iron metabolism-related proteins including transferrin (TF), TFR1, divalent metal transporter (DMT1), ferritin (FT) and FPN1, with the activity of these proteins depending largely on the concentration of iron ( Amino Acid Metabolism in Stroke System Xc and Stroke The system Xc cysteine/glutamate antiporter is a heterodimer composed of solute carrier family 3 member 2 (the SLC3A2 regulatory subunit) and SLC7A11(the solute carrier 7A11, also known as xCT

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At the cellular level, B12 acts as a cofactor for two critical enzymatic reactions: Methionine synthase converts homocysteine to methionine, essential for DNA methylation and synthesis Methylmalonyl-CoA mutase involved in fatty acid metabolism and myelin production By restoring adequate B12 levels, injections enable normal red blood cell maturation in the bone marrow, correcting the megaloblastic anaemia

12 , 331349 (2001) Fearnhead, R.W., Stack, M.V.: Tooth Enamel