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A critical threshold of mGSH loss is necessary to trigger mitochondrial apoptotic signaling

Furthermore, the European Chemicals Agency (ECHA) has acknowledged the induction transient DNA strand breaks by GLY in both in vitro and in vivo testing (ECHA 2022)

It is also documented that the expression of CD44 in Mller glial cells increases following chronic ocular hypertension, which can impair autophagy in these cells (due to microglia-secreted osteopontin signaling) and lead to loss of RGCs [169]

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