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Given the conserved chelating properties of transition metal complexes, existing clinical metal chelators can be repurposed and optimized for targeted platinum chelation, with priority given to strategies that reduce platinum accumulation in normal tissues while preserving intratumoral platinum concentrations

doi: 10.3748/wjg.v17.i12.1569 84 wichETunioATaciakMBarszczM

Thus, a growing body of evidence indicates that PrP is tightly integrated in the mechanisms regulating Cu transport and distribution in health and disease