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Immunoregulation Through the Mitochondrial Intermediate Succinate By producing NADH, the tricarboxylic acid (TCA) cycle is a central route for oxidative phosphorylation, fueling complex I of the electron transport chain and eventually ATP generation

Different targets and mechanisms

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This synaptic plasticity process involves several activities that alter synaptic proteins, including glutamate receptors (-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate and N-methyl-D-aspartate (NMDA), postsynaptic density protein 95 (PSD-95), and other kinases such as calmodulin-dependent kinase II (CaMKII) and protein kinase C (PKC), to modify the synaptic structure (Alhowail and Aldubayan, 2023

Table 1 Small molecule inhibitors that target various pathways in GBM