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Therapeutic targeting of STING-TBK1-IRF3 signalling ameliorates chronic stress induced depression-like behaviours by modulating neuroinflammation and microglia phagocytosis

Crucially, mitochondrial metabolism reprogramming is orchestrated by core regulatory pathways (such as the HIF axis, AMPK/mTOR signaling, and sirtuin-mediated deacetylation cascades), which collectively modulate pyruvate dehydrogenase (PDH) activity, ETC efficiency, and anaplerotic flux (56)

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Notably, MYC, a key transcription factor implicated in the cellular response to DILI and liver pathology, was among these targets 20,21

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