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Dysbiosis, through the lack of appropriate immunoregulatory and barrier factors, such as, e.g., short-chain fatty acids, causes inappropriate activation of the immune system, resulting in epithelial inflammation, epithelial barrier damage and disease development [55, 57,58,59,60,61]

The Transcellular Pathway: Transcytosis and Posterior Exocytosis An increased intestinal transcellular permeability found in different disease conditions has been postulated to be critical for the migration of bacteria and bacterial components such as endotoxins across the gut wall

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