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Under inflammatory conditions, pro-inflammatory cytokines [e.g., interferon-gamma (IFN-)] can activate IDO1, diverting Trp metabolism toward the kynurenine (KYN) pathway while inhibiting 5-HT synthesis, resulting in serotonin depletion and exacerbation of neurotransmitter imbalance (Rus et al., 2015)

Synthesis, biological studies and molecular dynamics of new anticancer RGD-based peptide conjugates for targeted drug delivery

Thus far, anti-CAM treatment has not been successful in patients with acute ischemic stroke

azathioprine, 6-mercaptopurine or in rare cases tioguanine)

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