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Different studies have shown that lipoic acid and NAC decrease levels of oxidative damage while also helping to protect mitochondrial function and against -amyloid accumulation 28 in the brain, which is a major cause of Alzheimer's

Significant levels of reduction were also noted in the CSF/plasma ratio of amino acids like glutamine, alanine, phenylalanine, and valine, giving a clear indication of amino acid metabolism disruption in neurodegenerative conditions (Basun et al

Sequence logos were generated from the multiple sequence alignment using the R package ggseqlogo 64

The suspension was centrifuged at 15,000 g for 20 min at 4C, and the resulting supernatant was used directly as an enzyme source ( SOD (EC 1.15.1.1) activity was determined based on the capacity of the enzyme to inhibit the photoreduction of nitroblue tetrazolium (NBT) ( CAT (EC 1.11.1.6) activity was assayed, according to the method of 1 cm 1 ) as a result of H 2 O 2 degradation

Thannickal VJ, Fanburg BL