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Similarly, gold nanoparticles with oxidase-like catalytic activities have advanced to clinical trials (e.g., NU-0129, NCT03020017) [163]

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Another potential mechanism of induced cellular toxicity due to the interaction of PUFAs with -syn could be the incorporation of the PUFAs themselves within the complexes, as has been shown for DHA, which would sequester and compartmentalize PUFAs thereby affecting their normal roles within the cell (Broersen et al., 2006)