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Should two infusions be indicated, these are carried out two weeks apart

In various tumors, the PI3K-AKT-mTOR signaling axis is frequently in an abnormally active state

Read on as we look at these symptoms in more detail in the next section

References 1 ManaviMAFathian NasabMHMohammad JafariRDehpourAR

Similarly, overexpression of ITGA2 in esophageal squamous cell carcinoma cell lines promoted EMT and metastasis through FAK/AKT pathway [49] and also showed chemotherapy resistance in gastric cancer, while ITGA2 knockdown restored chemosensitivity by inducing apoptosis in chemoresistant cells [50]