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Description

Endogenous TRPM7 expressed in mouse hippocampal neurons was inhibited by nafamostat with an IC 50 of 27 M in the presence of a low concentration (0.1 mM) of Ca 2+ and Mg 2+ in a bath solution, whereas the channels were unexpectedly found to be augmented by pre-application of nafamostat ( 2+ -independent manner, TRPM7 with an IC 50 of 0.630.86 M, compared to TRPM6 and TRPM8, presumably by interacting with multiple residues in the selectivity filter (Guan et al., 2021)