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Because the milligram amount is fixed, a lighter body gets more drug exposure per pound: roughly 22% more at 70 kg and about a third less at 120 kg, compared with a 90 kg reference. The dose still comes from response and tolerability, but a lighter person is running a hotter exposure at the same number on the vial

When given by injection, the molecular structure of the vitamin is not entirely attacked by the acids and enzymes of the digestive system

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There have been reports of anaphylactoid reactions in horses